| NADPH oxidase p22phox C242T 유전자 다형성이 8주간의 유산소성 훈련에 따른 운동수행능력 및 산화적 손상에 미치는 영향 |
| 조수연, 백일영, 진화은, 노희태 |
| 연세대학교 |
| The effect of NADPH oxidase p22phox C242T polymorphism on endurance exercise performance and oxidative damage in response to 8weeks aerobic exercise training. |
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| ABSTRACT |
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The purpose of this study was to investigate the effects of NADPH oxidase p22phox C242T polymorphism on endurance exercise performance and oxidative damage in response to acute and chronic exercise. Medically healthy 118 men and 112 women were analyzed with the genotype of p22phox C242T and then 48 men and women were finally selected and divided into two different polymorphism groups(CC genotype：24, T allele：24). Before and after exercise tests were measured at 85%VO2max until all-out and blood samples were taken 5 times(rest, end of exercise, after 30 min, 4 h and 24 h of recovery) to measure the concentration of plasma lactate, SOD(antioxidant enzyme) and lymphocyte DNA damage. 8 weeks of exercise training were performed 3 times a week at 70%HRR on the treadmill. The results of the research are as follows. it was shown that the eight-weeks aerobic training related to NADPH oxidase p22phox C242T genotype executed in this study not only increased maximal oxygen uptake and exercise performed time but also decreased the plasma lactate level. In addition, both CC genotype and T allele groups showed decreases in plasma SOD after the training and reductions in lymphocyte DNA damage as well. Furthermore, CC genotype than T allele showed a greater effect from the training. |
| Key words:
NADPH oxidase p22phox C242T polymorphism, aerobic training, lactate, SOD, DNA damage |
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