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Exerc Sci > Volume 11(2); 2002 > Article

Exercise Science 2002;11(2): 441-452.

The effect of exercise training on Amyloid-β and learning and memory behaviors in NSE/PS2m Alzheimer's disease model mice

조준용¹, 임예현², 이규성², 황대연³, 김용규³

¹한국체육대학교
²KNUPE
³KFDA

ABSTRACT

Cho, J.Y., Leem, Y.H., Lee, K.S., Hwang, D.H., Kim, Y.K. Elevation of Aβ42 has been confirmed in the skeletal muscle of Alzheimer's Disease (AD) patients. Exercise Science,11(2): 441-452, 2002. We used the transgenic model of AD that express a human mutant PS2 (N141I) transgene (hPS2m) under the regulation of the rat neuron-specific enolase (NSE) promoter. These transgenic mice have behavioral deficit at 12 months of age that are accompanied by increasing levels of Aβ42. Unexpectively, mice expressed skeletal muscle-specific expression of hPS2m gene that had previously been confined to the brain. We examined the protective effect of exercise on Aβ42 deposits in the skeletal muscle, brain, behavioral deficit, and serum cholesterol of transgenic mice respectively. To investigate this, the transgenic mice were subjected to treadmill exercise during the course of the experiment. Upon treatment, the levels of the Aβ42 deposits were significantly reduced in both the skeletal muscle and the brain, and also behavioral deficits were improved. In addition, TG and LDL levels were significantly reduced. The results suggest that treadmill exercise in transgenic mice resulted in reduction at the low levels of cholesterol, thereby reducing Aβ42 secretion. Thus, these transgenic mice are useful experimental system in which to study the protective effect of exercise on improving behavioral function and reducing Aβ42 deposition in the skeletal muscle and brain of transgenic mice. Treadmill exercise may represent practical strategy applying for human subjects with Alzhei- mer's Disease in the preventive management on the basis of these scientific evidences.

Key words: PS2m, Alzheimer Disease, Cholesterol