Change of lipid metabolism during exercise  according to UCP2 gene polymorphism in obesity man

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Exerc Sci > Volume 14(1); 2005 > Article

Exercise Science 2005;14(1): 11-19.

비만인의 UCP-2 유전자 다형에 따른 운동 중 지방대사의 변화

안의수¹, 이지영²

¹성균관대학교
²포항공과대학교

Change of lipid metabolism during exercise according to UCP2 gene polymorphism in obesity man

ABSTRACT

Ann, E.S., Lee, J.Y. Change of lipid metabolism during exercise according to UCP2 gene polymorphism in obesity man. Exercise Science, 14(1): 11-20, 2005. The purpose of the study was to compare lipid metabolism during treadmill exercise according to the UCP2 gene I/D polymorphism. A total of 39 apparently healthy volunteers (ID, n=10; DD, n=29; aged 20-30 years) were recruited via flyers and local advertisements. Anthropometric measurements included body weight, height, percent body fat, and cardio-respiratory fitness. Following an overnight fasting, the subjects performed exercise to 40% of VO2max on treadmill for 1 hour. Blood samples were collected from an anticubital vein into blood collecting tubes at rest, exercise 30minute, exercise 60minute, and recovery 1hour. The collected samples were used for analyses of blood lactate, glucose, triacylglicerol, free fat acid. And the respiratory exchange ratios were directly obtained from a metabolic cart every 10 minutes. Two-way analyses of variance showed a significant interaction effect between group and repetition(according to time) in blood lactate. In genotype comparison, DD homzygotes had significantly higher resting triacylglycerol and lactate concentrations than ID heterozygotes. The current findgs of the study suggest that although the UCP2 gene polymorphism itself is not related to lipid metabolism during exercise, the UCP2 D allele can be a genetic marker to the risks of obesity and cardiovascular disease.

Key words: UCP2 gene polymorphism, lipid metabolism, obesity, exercise