Effects of Exercise Intensity on Sciatic Function Index(SFI) and gastrocnemius muscle GLUT-4 Protein Expression After Sciatic Nerve Injury in Rats

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Exerc Sci > Volume 14(3); 2005 > Article

Exercise Science 2005;14(3): 281-288.

운동 강도가 좌골 신경 손상 쥐의 기능 회복과 비복근 GLUT-4 단백질 발현에 미치는 영향

박상덕¹, 임은미¹, 서태범², 정일규¹, 윤진환¹, 이희혁¹, 박성태¹, 김경래³

¹한남대학교
²경희대학교
³서울대학교

Effects of Exercise Intensity on Sciatic Function Index(SFI) and gastrocnemius muscle GLUT-4 Protein Expression After Sciatic Nerve Injury in Rats

ABSTRACT

Park, S.D., Park, S.T., Seo, T.B., Lee, H.H., Im, E.M., Jeong, I.K., Yoon, J.H., Kim, K.l. Effects of Exercise Intensity on Sciatic Function Index(SFI) and gastrocnemius muscle GLUT-4 Protein Expression After Sciatic Nerve Injury in Rats. Exercise Science, 14(3), 281-288, 2005. Physical activity can improve sensorimotor recovery and GLUT4 expression after peripheral nerve injury. Here, we describe effects of exercise intensity in glucose uptake facilitated by training. Using Western blot, we identified highly enhanced GLUT4 expression in sciatic nerve of rats with low-intensity treadmill training after crush injury compared with middle-intensity and high-intensity treadmill exercise group. Also we carried out foot-printing method to investigate motor functional recovery after sciatic nerve injury. Low-intensity treadmill exercise group promoted Sciatic Functional Index(SFI) values compared with middle-intensity and high-intensity treadmill exercise group. Thus, the present data provide a new evidence that low-intensity treadmill training enhanced GLUT4 expression and Sciatic Functional Index values after sciatic nerve injury in rats.

Key words: Exercise, sciatic nerve, SFI, GLUT-4