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Exerc Sci > Volume 18(1); 2009 > Article
Exercise Science 2009;18(1): 21-30. doi: https://doi.org/10.15857/ksep.2009.18.1.21
젊은 성인의 아디포넥틴 유전자 다형(G276T)과 비만, 인슐린 저항성, 심폐체력과의 관계
김태경1, 강현식2, 조진경2, 정정욱2
Association of adiponectin genotype (G276T) with obesity, insulin resistance, and cardiorespiratory fitness in young adults
Adiponectin, an adipose tissue specific protein, has been localized metabolic syndrome and type 2 diabetes gene, increased insulin senstivity following promotes muscle glucose uptake and fatty acid oxidation. Serum adiponectin concentrations were significantly decreased in subjects with obesity and chronic diseases including type 2 diabetes, study of adiponectin genotype is continuous with clinical characteristic. This study was to investigate whether or not the adiponectin single nucleotide polymorphism(G276T) was associated with obesity, insulin resistance, and cardiorespiratory fitness(CRF) in apparently healthy and young adults. The SNP G276T genotype was assessed in a total of 677 college students(475 men and 202 women) by using the Real-Time Quantitative PCR. CRF was measured as the maximum volume of minute oxygen consumption during a graded treadmill testing. Body composition(body mass index, percent body fat, waist circumference) and blood chemistry(fasting glucose, fasting insulin, adiponectin) were measured by using our standardized protocols. With respect to SNP G276T variants, group analyses showed that those with GG genotype had significantly higher homeostasis model assessment of insulin resistance(HOMA-IR) and fasting insulin than those with GT and TT genotype. The findings of the current study suggest that the adiponectin gene SNP G276T polymorphism may be used as a genetic marker to insulin resistance at least in young adults.
Key words: adiponectin single nucleotide polymolphism, adiponectin, insulin resistance, cardiorespiratory fitness
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