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Exerc Sci > Volume 21(3); 2012 > Article
Exercise Science 2012;21(3): 347-354. doi: https://doi.org/10.15857/ksep.2012.21.3.347
베타-아드레날린 수용체의 활성이 골격근 내 미토콘드리아 생합성에 미치는 영향
김상현, 김기진
The effect of β-AR on mitochondrial biogenesis in rat skeletal muscle.
Mitochondrial biogenesis by activation of β-adrenergic receptor(β-AR) with catecholamine in skeletal muscle was the object of interest for several decades. Several recent studies argue that because catecholamine formation is increased during exercise, mitochondrial biogenesis is also increased by catecholamine action in skeletal muscle. This study measured PGC-1α and mitochondrial electron transport enzymes to evaluate the mitochondrial biogenesis by β-adrenergic stimulates in rat skeletal muscle. Rats were subcutaneously injected with norepinephrine and clenbuterol(β-adrenergic agonist) for mitochondrial biogenesis by β-AR activation in brown adipose tissue(BAT) and skeletal muscle. Also propranolol(β-adrenergic antagonist) and AICAR was injected subcutaneous to determine whether catecholamine and necessary for exercise induced mitochondrial biogenesis. Norepinephrine and clenbuterol increased PGC-1α mRNA and protein expression in BAT, but they had no effect on PGC-1α and mitochondrial electron transport enzymes in skeletal muscle. While AICAR increased PGC-1α mRNA expression, propranolol suppression of PGC-1α mRNA expression did not occur, and was actually expressed more than AICAR treated group.
Key words: Catecholamine, β-adrenergic receptor, PGC-1α, Mitochondrial biogenesis, Exercise, AICAR, Skeletal muscle
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