| 수영운동과 DA-9601투여가 흰쥐의 소화기계에서 IL-8, TNF-a와 COX-2유전자 발현에 미치는 영향 |
| 최은주, 차광석 |
| 건국대학교 |
| The effects of the IL-8, TNF-a and COX-2 gene expression on DA-9601 administration and swimming exercise in small intestine and colon. |
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| ABSTRACT |
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The purpose of this study is to identify how DA-9601 administration and swimming exercise effect to Inflammatory Cytokines and Chemokine in digestive system. To perform this experiment, we prepared 20 BALB/c mice and divided into 4 groups(5 rats in each group). These 4 groups were designated as followings：control group(con), DA administration group(DA), exercise group(EX) and exercise group with DA-9601 administration(EX+DA). DA-9601 was steadily administered(50 mg/g/day) during 30 minutes before swimming exercise, and the organization was removed from small intestine and colon after the last exercise training. From above process, we identified that inflammatory cytokines IL-8, TNF-a, COX-2 genes were steadily increased in exercise group(EX), and they were significantly decreased in an exercise group which was DA-9601 ingested(DA+EX). As a result of this experiment, we inferred that high-intensity exercise such as a swimming exercise can cause an inflammatory condition of the environment by increasing inflammation-related genes in digestive system. Therefore, DA-9601 administration which has antioxidant and anti-inflammatory effect would be necessary to repress inflammatory cytokines due to exercise. Also, ingestion with antioxidant products is ideally considered and recommended in order to repress the Inflammation in intestines. |
| Key words:
DA-9601, Swimming exercise, Colon, Small intestine, Cytokine |
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