The Effect of 12 weeks of Exercise Training on Peroxisome proliferator activated receptor γ in Aorta of Hypertensive Rats.

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doi:2012.21.3.355

Exerc Sci > Volume 21(3); 2012 > Article

Exercise Science 2012;21(3): 355-364. doi: https://doi.org/10.15857/ksep.2012.21.3.355

12주간 지구성 트레드밀 운동이 고혈압쥐 대동맥의 Peroxisome proliferator activated receptor γ발현에 미치는 영향

윤아람¹, 이영란², 권순미², 장학영², 이위², 이왕록², 이상기², 전종귀², 박희근²

¹을지의과대학교 의과대학 해부학 및 신경과학 교실
²충남대학교

The Effect of 12 weeks of Exercise Training on Peroxisome proliferator activated receptor γ in Aorta of Hypertensive Rats.

ABSTRACT

The purpose of this study was to investigate the expression of PPAR-γ, inflammatory cytokines and antioxidant proteins in aorta by 12 weeks of endurance exercise training. The Wistar-Kyoto rats(WKY, n=16) and Spontaneously hypertensive rats(SHR, n=16) were divided into 4 groups; WKY control(WC), WKY exercise(WE), SHR control(SC), SHR exercise(SE), and submitted to treadmill exercise for 12 weeks(5 days/week, 30~60 min/day). Every other weeks, body weight and systolic blood pressure were measured. 24 hours after last exercise, all rats were sacrificed then, blood lipid profiles were measured and the expression of PPAR-γ, inflammatory cytokines and antioxidant proteins were analyzed by western blotting. The expression of PPAR-γ of WE and SE were significantly increased compared with WC and SC. MCP-1 and TNF-α were significantly decreased in SE, but IL-1β shows no differences. Mn-SOD and HSP70 were significantly increased by exercise in WE and SE. Therefore, we suggested that endurance exercise could increase the PPARγ expres sion and decrease the inflammatory cytokines and increase antioxidant proteins and it plays a important role in ameliorating the hypertension.

Key words: Hypertension, Aorta, Peroxisome proliferator activated receptor γ, Inflammatory cytokines, Exercise