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Exerc Sci > Volume 23(2); 2014 > Article
Exercise Science 2014;23(2): 181-191. doi: https://doi.org/10.15857/ksep.2014.23.2.181
트레드밀 운동이 헌팅턴병 유발 쥐의 뇌신경세포생성과 사멸 및 신경가소성에 미치는 영향
김유미1, 김창주2, 김태운2, 지은상3, 서태범2, 윤진환1
3상명대학교 체육학과
The Effects of Treadmill Exercise on Neurogenesis, Apoptosis and Neuroplasticity in Huntington's Disease Rat Model
The aim of the present study was to investigate the effects of treadmill exercise on neurogenesis (Ki-67), apoptosis (Bid, Bcl-xl), and spatial memory (Y-maze test) in the huntington's disease rat model. Forty male rats were divided into sham-operation group (n=10), sham-operation & treadmill exercise group (n=10), Huntington's disease group (n=10), and Huntington's disease & treadmill exercise group (n=10) at the age of 6 weeks. Rats in the treadmill exercise group performed treadmill exercises (5 days/week, 30 min/day) for 2 weeks. The present results found Huntington's disease & treadmill exercise group significantly enhanced hippocampal neurogenesis, apoptosis, and spatial memory compared to the Huntington's disease group (p<0.05). These results indicate that treadmill exercise improves brain functions of rats with Huntington’s disease.
Key words: Huntington's disease, treadmill exercise, neurogenesis, apoptosis, spatial memory
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