| 트레드밀 달리기가 어미와 분리시킨 새끼 쥐의 해마에서 c-Fos 발현에 미치는 영향 |
| 백성수1, 전태원1, 김성수2, 김창주3, 박성태4, 신말순3, 김홍3 |
1서울대학교
2고려대학교
3경희대학교
4경주대학교 |
| Effects of treadmill running on hippocampal c-Fos expression in the maternal-separated rat pups |
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| ABSTRACT |
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Baek, S.S., Jun, T.W., Park, S.T., Shin, M.S., Kim, C.J. Kim, H., Kim, S.S. Effects of treadmill running on hippocampal c-Fos expression in the maternal-separated rat pups. Exercise Science, 15(1), 25-34, 2006. The early loss of maternal relationship may increase the vulnerability of the infants to neuropsychiatric disorders such as childhood anxiety disorders, personality disorders, and depression. In the present study, the effect of postnatal treadmill running on the hippocampal c-Fos expression in the maternal-separated rat pups was investigated. Male and female Sprague-Dawley rat pups (35 ± 10 g and 2 weeks old, n = 65) were used in this experiment. On the postnatal day 14, the rat pups from seven rat mothers were assigned into one of five groups (n = 13 in each group): the maternal care group, the maternal care with exercise group, the maternal separation group, the maternal separation with exercise group, and the maternal separation with fluoxetine-treatment group. The results of this study showed that maternal separation significantly suppressed the hippocampal c-Fos expression in the rat pups, while c-Fos expression was enhanced by performing treadmill running. In conclusion, the present findings show that a participation in regular exercise program may be a useful strategy to prevent or cure those who suffer from decreased neuronal activity induced by maternal separation in childhood. |
| Key words:
maternal-separated rat pups, treadmill running, c-Fos expression, hippocampus |
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