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Exercise Science 2005;14(4): 555-568. |
Low intensity exercise training alters pathological cardiac hypertrophy molecular phenotypes and apoptosis regulatory proteins in Spontaneously hypertensive rat |
이영익1, 남기태2, 김윤만1, 오윤선3, 조준용1, 양춘호4, 조인호1, 김철현1, 엄현섭1, 김명기1, 황대연2, 이규성1 |
1한국체육대학교 2국립독성연구소 3상명대학교 4한서대학교 |
Low intensity exercise training alters pathological cardiac hypertrophy molecular phenotypes and apoptosis regulatory proteins in Spontaneously hypertensive rat |
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ABSTRACT |
Lee, Y.I., Kim, C.H., Cho, I.H., Um, H.S., Kim, Y.M., Kim, M.K., Oh, Y.S., Yang, C.H., Hwang, D.Y., Nam, K.T., Lee, K.S., Cho, J.Y. Low intensity exercise training alters pathological cardiac hyper trophy molecular phenotypes and apoptosis regulatory prote ins in spontaneously hypertensive rat(SHR). Exercise Science, 14(4): 555-568, 2005. This study was designed to dete rmine the effects of exercise training on cardiac function, myocardial gene expression, and apoptosis. Exercise-trained SHR showed clear adaptive changes such as reduced body weight, heart rate, blood pressures, left ventricle wall thic kness, lipid profiles, and homocysteine level. The mRNA expression of angiotensin convert ting enzyme, endothelin -1, and brain natriuretic peptides in the heart was significa ntly higher in the non-exercise SHR, whereas mRNA expres sion of caveolin-3 and eNOS in the heart was significantly lower in the non-exercise SHR. Bcl-2 protein levels were significantly higher in the exercise-trained SHR. In contra st, Bax protein levels were significantly higher in the non- exercise SHR. Further more, the levels of the active forms of caspase-3 were significantly lower in the WKY. These findings suggested that endurance exercise training interfered with a signal transduction pathway of apoptosis seconday to the pathological cardiac hypertrophy. |
Key words:
spontaneously hypertensive rat, pathological cardiac hypertrophy, apoptosis, treadmill exercise |
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