The effect of running exercise training on GLUT4 and VAMP2 protein expression in soleus muscle of streptozotocin-induced diabetes rats

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Exerc Sci > Volume 14(4); 2005 > Article

Exercise Science 2005;14(4): 545-554.

달리기 운동이 streptozotocin-유도 당뇨쥐의 가자미근 당수송체(GLUT4)와 소포관련 막단백질(VAMP2) 발현에 미치는 효과

박성태¹, 백성수², 이희혁¹, 서태범³, 정일규¹, 김종오¹, 윤진환¹, 오명진⁴, 정영수⁵

¹한남대학교
²서울대학교
³경희대학교
⁴백석대학교
⁵명지전문대학

The effect of running exercise training on GLUT4 and VAMP2 protein expression in soleus muscle of streptozotocin-induced diabetes rats

ABSTRACT

Park, S.T., Seo, T.B., Baek, S.S., Chung, Y.S., Oh, M.J., Kim, J.O., Lee, H.H., Jeong, I.G., Yoon, J.H. The effect of running exercise training on GLUT4 and VAMP2 protein expression in soleus muscle of streptozotocin-induced diabetes rats. Exercise Science, 14(4), 545-554, 2005. The purpose of this study was to examine the effect of exercise training on GLUT4 and VAMP2 protein expression in soleus muscle of streptozotocin(STZ)-induced diabetes rats. Sprague- Dawley rats were randomly divided into four groups : normal control(NC, n=6), normal exercise(NE, n=6), diabetes control(DC, n=6) and diabetes exercise(DE, n=6). Exercise training groups were made to run on a motorized treadmill by moderate intensity for 30 min a day, five days for 6 weeks. The results of this study were that in blood glucose level, STZ-induced diabetes rats were remarkably higher than normal rats and DE was significantly low compared to DC. Expression of GLUT4 and VAMP2 protein in DC were significantly low compared to NC, NE and DE was significantly higher than DC. In conclusion, we suggest that exercise training increase expression of GLUT4 and VAMP2, proteins involved with glucose uptake, so these effects can decrease STZ- induced blood level.

Key words: exercise training, insulin, GLUT4, VAMP2