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Exerc Sci > Volume 21(4); 2012 > Article
Exercise Science 2012;21(4): 417-424. doi: https://doi.org/10.15857/ksep.2012.21.4.417
아동의 PPARGC1A 유전자형(Gly482Ser)과 신체활동, 비만지표, 대사성위험인자와의 연관성
안의수, 최규환, 조진경, 하창덕, 강현식
Relationships of the PPARGC1A genotypes with physical activity, body fatness and metabolic risk factors in children.
The purpose of the study was to investigate the genetic effect of the PPARGC1A gene on body fatness and metabolic risk factors in Korean children. A single nucleotide polymorphism (SNP) of Gly482Ser(rs8192678) in the PPARGC1A gene was genotyped by using a Taqman assay in a total of 283 children (boys=150 & girls=133, aged 8 to 12 years) who were recruited from local elemental schools. Primary outcomes of the study included body composition parameters including weight, height, body mass index, waist circumference, percent body fat and waist-to-hip ratio and metabolic risk factors including resting blood pressures, triglycerides, total cholesterol, high-density lipoprotein cholesterol, fasting glucose, insulin and homeostasis assessment model of insulin resistance(HOMA-IR). One-way ANOVA followed by bonferroni post-hoc tests was used to test any significant associations between the measured variables and genotype at a statistical significance of p=.05. The Ser482Ser genotype had significantly higher values in body weight (p=.016), percent body fat (p=.009), hip (p=.038) and body mass index (p=.090) than either the Gly482Gly or Gly482Ser genotype. The findings of the study suggest that the Ser482Ser genotype might play as a predisposed risk for obesity in Korean children.
Key words: Children, Gly482Ser SNP, Physical activity, Body Fatness, Metabolic Risk Factors
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