Relationship between Gln223Arg polymorphism in the leptin receptor gene and body composition in middle-aged women

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Exerc Sci > Volume 13(2); 2004 > Article

Exercise Science 2004;13(2): 233-240.

중년 여성의 렙틴 수용체 유전자 다형성과 신체구성상 특성의 관련성

김기진¹, 홍창배¹, 안나영¹, 천우광¹, 박주식², 신윤정¹, 김상현¹, 김태호¹, 이지은¹

¹계명대학교
²경주대학교

Relationship between Gln223Arg polymorphism in the leptin receptor gene and body composition in middle-aged women

ABSTRACT

Relationship between Gln223Arg polymorphism in the leptin receptor gene and body composition in middle-aged women. Exercise Science, 13(2): 233-240, 2004. Previous studies have been found for the polymorphism in the leptin receptor gene being involved in human obesity. We examined relationship between the Gln223Arg polymor- phism in the leptin receptor gene and body composition. Subjects were consisted of obese group (N=94) and normal weight group (N=95) in middle-aged women. Body weight, %fat, BMI, skinfold thickness, body circumferences, and WHR were measured for the analysis of the detailed physique. Leptin receptor polymorphism was detected by PCR-RELP assays. The Gln223Arg polymorphism in the leptin receptor gene was no significant difference between obese and normal weight group, and heterozygous for the leptin receptor gene showed the highest values in both groups. The allele frequency was no significant difference between obese and normal weight group. Body weight and BMI showed a significant (p<0.05) difference between mutant homozygous and heterozygous of the Gln223Arg in the leptin receptor gene in both groups. Hip and thigh circumferences showed a significant (p<0.05) difference between mutant homozygous and heterozygous of Gln223Arg in the leptin receptor gene in both groups. Although it was no significance, skinfold thickness of mutant homozygous group showed a higher values than mutant heterozygous group in obese group. Therefore the Gln223Arg polymorphism of the leptin gene receptor not appeared to be a risk factor for obesity in middle-aged Korean women, but we suggest that the Gln223Arg polymorphism of the leptin gene receptor affect to the body composition.

Key words: obesity, leptin receptor gene, Gln223Arg