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Exerc Sci > Volume 13(2); 2004 > Article
Exercise Science 2004;13(2): 211-222.
지구성 운동강도 차이가 streptozotocin 유발 당뇨쥐의 인슐린 및 골격근 제4형 당수송체(GLUT-4) 발현에 미치는 영향
김영표1, 채정룡2, 김종오1, 서태범3, 윤진환1, 김창주3, 정일규1, 김홍3
1한남대학교
2군산대학교
3경희대학교
The effect of exercise intensity on blood insulin and GLUT-4 protein expression of skeletal muscle in STZ-diabetic rats
ABSTRACT
The effect of exercise intensity on blood insulin and GLUT-4 protein expression of skeletal muscle in STZ-diabetic rats. Exercise Science, 13(2): 211-222, 2004. The pupose of this study was to investigate the effect of exercise intensity on blood insulin and glucose transporter 4 (GLUT-4) protein expression of skeletal muscle in STZ-diabetic rats. Male Sprague-Dawley rats were randomly divided into normal, diabetes(DM), diabetic low-intensity exercise(DLE), and diabetic high-intensity exercise(DHE) groups. Animals of the exercise groups were put on running for 30 min once a day, 5days per week for 4 weeks. The regimen of low-intensity exercise consisted with running at speed of 10 m/min, high- intensity exercise was 24 m/min, on 0% grade. In the present results, weight gain of the rats in DM, DLE, and DHE groups was significantly lowered compared to normal group, and decreased by exercise. Plasma glucose concentration in DM, DLE, and DHE groups was significantly higher than that of normal group, the concentration of DLE group was significantly lower than that of DM, DHE group in 3 and 4 weeks. Plasma insulin concentration in normal, DLE groups was significantly highered in compared to DM, DHE groups, and the conce- ntration of DHE group was significantly higher than that of DM group. GLUT-4 protein level of soleus in DM group was remarkably decreased compared to normal group, but the level was recovered to the level of normal group by 4 week low-intensity exercise. In conclusion, the insulin resistance induced by STZ administration was partially improve by 4 week low-intensity endurance exercise.
Key words: exercise intensity, insulin, GLUT-4, STZ
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