| 트레드밀 운동이 추위 스트레스에 의한 생쥐 해마의 신경세포 사멸에 미치는 영향 |
| 김기정1, 이신호2, 김창주3, 지은상4, 백성수5 |
1서울대학교
2성균관대학교
3경희대학교
4한서대학교
5상명대학교 |
| Effect of treadmill exercise on cold stress-induced apoptotic neuronal cell death in the hippocampus in mice |
|
|
|
|
|
|
|
| ABSTRACT |
|
In the present study, the effect of treadmill exercise on chronic intermittent cold stress-induced apoptotic neuronal cell death in the hippocampus of mice was investigated. Male ICR mice were divided into four groups: the control-rest group; the control-exercise group; the cold-rest group; and the cold-exercise group (n = 5 in each group). In the present study, the chronic intermittent cold stress was induced by exposure of mice to cold room at 4℃ for 3 h once a day, 6 times per week during 3 weeks. The treadmill exercise load consisted of running at a speed of 5 m/min for 30 min once a day, 6 times per week for 3 weeks. Immunohistochemistry for caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling(TUNEL) staining were performed to determine apoptotic neuronal cell death in the hippocampal dentate gyrus. Our results revealed that the expression of caspase-3 and the number of TUNEL-positive cells were significantly increased by cold stress (p<.05), and treadmill exercise significantly suppressed the expression of caspase-3 and the number of TUNEL-positive cells after cold stress (p<.05). The findings of our study provide evidence that treadmill exercise may ameliorate the brain damage induced by cold stress. |
| Key words:
cold stress, treadmill exercise, apoptotic neuronal cell death, mice |
|
PDF Links
Full text via DOI
Download Citation 
