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Exerc Sci > Volume 18(4); 2009 > Article
Exercise Science 2009;18(4): 497-504. doi: https://doi.org/10.15857/ksep.2009.18.4.497
트레드밀 운동이 추위 스트레스에 의한 생쥐 해마의 신경세포 사멸에 미치는 영향
김기정1, 이신호2, 김창주3, 지은상4, 백성수5
1서울대학교
2성균관대학교
3경희대학교
4한서대학교
5상명대학교
Effect of treadmill exercise on cold stress-induced apoptotic neuronal cell death in the hippocampus in mice
ABSTRACT
In the present study, the effect of treadmill exercise on chronic intermittent cold stress-induced apoptotic neuronal cell death in the hippocampus of mice was investigated. Male ICR mice were divided into four groups: the control-rest group; the control-exercise group; the cold-rest group; and the cold-exercise group (n = 5 in each group). In the present study, the chronic intermittent cold stress was induced by exposure of mice to cold room at 4℃ for 3 h once a day, 6 times per week during 3 weeks. The treadmill exercise load consisted of running at a speed of 5 m/min for 30 min once a day, 6 times per week for 3 weeks. Immunohistochemistry for caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling(TUNEL) staining were performed to determine apoptotic neuronal cell death in the hippocampal dentate gyrus. Our results revealed that the expression of caspase-3 and the number of TUNEL-positive cells were significantly increased by cold stress (p<.05), and treadmill exercise significantly suppressed the expression of caspase-3 and the number of TUNEL-positive cells after cold stress (p<.05). The findings of our study provide evidence that treadmill exercise may ameliorate the brain damage induced by cold stress.
Key words: cold stress, treadmill exercise, apoptotic neuronal cell death, mice
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