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Exerc Sci > Volume 19(2); 2010 > Article
Exercise Science 2010;19(2): 105-114. doi: https://doi.org/10.15857/ksep.2010.19.2.105
트레드밀 운동에 의한 MAPK 관련 전사인자 활성화가 축삭 재생과 탈신경된 가자미근의 비대에 미치는 효과
윤진환, 정일규, 김연희
한남대학교
Effects of axonal regeneration and hypertrophy in denervated soleus muscle on MAPK-regulated transcription factors activated by treadmill exercise
ABSTRACT
Effects of axonal regeneration and hypertrophy in denervated soleus muscle on MAPK-regulated transcription factors activated by treadmill exercise. Exercise Science, 00(0):00-00, 2010. The main objective of this study was to investigate the effect of exercise-activated ErK1/2 and c-Jun pathway on axonal regeneration and hypertrophy of denervated soleus muscle. Rats were randomly divided into three groups: control group (n=60), sedentary group after sciatic nerve injury (n=60, sedentary group 1, 3, 7, 14, 21 and 28 after injury) and treadmill exercise group after sciatic nerve injury (n=60, exercise group 1, 3, 7, 14, 21 and 28 after injury. Two days after injury, animals in the exercise group were forced to run on treadmill for 30 min once a day for 5 consecutive days. present result demonstrated that treadmill exercise further increased axonal regrowth in the region 10 mm distal to the injury site from 14 days post injury and upregulated GAP-43 induction levels than those in the sedentary group 28 days after injury. expression levels of p-Erk1/2 and p-c-Jun were significantly increased in treadmill training compared to the sedentary group 3 and 7 days after injury. Treadmill exercise after sciatic nerve injury not only prevented atrophy of the soleus muscle but also significantly increased cross-sectional area of the skeletal muscle at 21 and 28 days. The present data suggest that increased p-Erk1/2 and p-c-Jun by treadmill exercise may play an important role in the axonal regeneration and skeletal muscle hypertrophy after sciatic nerve injury.
Key words: 트레드밀 운동, 축삭재생, 좌골신경 손상, 가자미근 비대
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