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Exerc Sci > Volume 12(4); 2003 > Article

Exercise Science 2003;12(4): 653-662.

운동수행에 따른 쥐의 골격근 형태별 UCP-3 mRNA의 변화

양대승¹, 김문희², 이승국³, 김철현³, 오유성⁴, 조준용³, 방상식⁵, 이규성³

¹대덕대학교
²대림대학교
³한국체육대학교
⁴강원관광대학
⁵국군체육부대

ABSTRACT

Yang, D.S., Kim, C.H., Leem, Y.H., Kim, M.H., Lee, S.K., Bang, S.S., Oh, Y.S., Cho, J.Y., Lee, K.S. The changes of UCP-3 mRNA of obese Zucker rats during exercise training. Exercise Science, 12(4): 653-662, 2003. The factors that regulate gene expression of uncoupling protein-3 (UCP-3) in skeletal muscle are poorly understood, but uncoupling protein-3 gene is clearly responsive to the metabolic state of organism. Therefore, We tested the hypothesis that chronic endurance exercise would alter UCP-3 gene expression. After 12wk endurance treadmill exercise, UCP-3mRNA levels of trained obese Zucker rat were decreased [vs. lean-type Zucker rat (100%) vs. obese Zucker rat control] in all two tissues. In addition, cholesterol, triglyceride and LDL-C levels were significantly reduced in trained rats, whereas citrate synthase activites were significantly increased in trained rats. The results of this study show that a need for a higher metabolic efficiency is associated with decreased mRNA expression of the uncoupling protein-3 (UCP-3) which would decrease energy dissipation in these tissues.

Key words: treadmill running, uncoupling protein-3 mRNA, citrate synthase