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Exerc Sci > Volume 11(2); 2002 > Article
Exercise Science 2002;11(2): 359-369.
지구성 운동이 흰쥐 해마에서 산화질소합성효소 발현에 미치는 영향
김영표1, 이계영2, 정일규1, 최덕구1, 김성수3, 신말순4, 김창주4, 윤진환1
1한남대학교
2대진대학교
3고려대학교
4경희대학교
ABSTRACT
Kim, Y.P., Yoon, J.H., Jeong, I.G., Choi, D.G., Lee, G.Y., Kim S.S., Shin, M.S., Kim, C.J., Effect of endurance exercise on nitric oxide synthase expression in hippocampus of rats. Exercise Science 11(2): 359-370, 2002. The effect of endurance exercise on nitric oxide synthase expression in the dentate gyrus, CA1, CA2 and CA3 of the hippocampus was investigated via nicotinamide adenine dinucleotide phosphate -diaphorase (NADPH-d) histochemistry. Male Sprague -Dawley rats were randomly divided into the three groups: the control group, the low-intensity exercise group, the moderate-intensity exercise group n=8 in each group. Animals of the exercise groups were put on running for 30min once a day, 5 days per week for 4 weeks. The regimen of the low-intensity exercise consisted with running at speed of 3 m/min for the first 5 min, 5 m/min for the next 5 min, then 8 m/min for the last 20 min, while the regimen for the moderate-intensity exercise was made with running at speed of 16 m/min for the first 5 min, 19 m/min for the next 5 min, then 22 m/min for the last 20 min. In the present results, weight gain of the rats in the moderate-intensity exercise group was significantly decreased compared to the control group and mild-intensity exercise group. In the moderate-exercise intensity group, NOS expression was significantly than lower the control and low-intensity exercise group in the dentate gyrus (p<.001), CA1 (p<.01), CA2 and CA3 (p<.001). It can be suggested that endurance exercise may prevent cell damage by inhibiting NOS expression of hippocampus.
Key words: Endurance exercise, nitric oxide synthase, hippocampus
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