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Exerc Sci > Volume 16(3); 2007 > Article
Exercise Science 2007;16(3): 193-200. doi: https://doi.org/10.15857/ksep.2007.16.3.193
운동 후 인슐린 감수성: AS160, 글리코겐 농도 및 AMPK의 역할
김정훈1, Gregory, D. C.2, 윤재량3
2University of Michigan
Postexercise Insulin Sensitivity: The Roles of AS160, Glycogen Concentration and AMPK
Kim, J.H., Yoon, J.R., Gregory D. Cartee. Postexercise Insulin Sensitivity: The Roles of AS160, Glycogen Concentration and AMPK. Exercise Science, 16(3): 193-200, 2007. Increase in insulin sensitivity is defined as improved ability of insulin to transport glucose in the cell in postexercise period. Prior exercise can induce more GLUT4 translocation by physiological insulin concentrations, suggesting that insulin signalling is amplified in postexercise period. How exercise can amplify insulin signaling is not cleary understood. However, the following hypothesis is generally convincing for its mechanisms. (1) Akt substrate 160 kD(AS160) is a newly found signaling protein which potentially plays an important role in GLUT4 translocation in response to insulin and is believed to in involved in exercise-induced increase in insulin sensitivity in skeletal muscle. (2) Glycogen depletion induced by vigorous exercise may induce amplification of insulin signaling, resulting in increased insulin sensitivity in skeletal muscle. (3) 5‘-AMP-Activated Protein Kinase(AMPK) activated during exercise can affect insulin signaling and thereby its sensitivity in postexercise period.
Key words: Exercise, Insulin Sensitivity, Glucose Transport
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