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Exerc Sci > Volume 23(1); 2014 > Article
Exercise Science 2014;23(1): 41-48. doi: https://doi.org/10.15857/ksep.2014.23.1.41
일회성 유산소 운동 후 회복기 동안 골격근 내 미토콘드리아 mitophagy 관련 인자의 변화
강윤석, 김재철
전북대학교
The Change of Mitophagic Factors in Mitochondria of Skeletal Muscle during the Period of Recovery by an Acute Aerobic Exercise
ABSTRACT
The aim of this study was to investigate the expression of mitophagy-related factors such as p53, NF-κB and PGC-1α protein in the skeletal muscle of Sprague-Dawley rats after an acute endurance exercise(20 m/min, 0°, 60 min, recovery 2 or 4 hours) at 70 % VO2max intensity. The expression of p53, NF-κB and PGC-1α protein in skeletal muscle was analyzed through the method of Western blotting. The expression of p53 protein was significantly increased in both 2- and 4-hour recovery period groups compared with before exercise in each of the soleus and EDL muscle. RelA/p65 protein was significantly increased in the soleus muscle during the recovery period compared with before exercise, but not remarkably increased in EDL muscle. PGC-1α protein was significantly increased in the soleus muscle in the only 2-hour recovery period group compared with before exercise, and increased in both 2- and 4-hour recovery period groups in EDL muscle. The results suggest that the acute endurance exercise may have induced mitochondrial mitophagy, leading to the expression of p53, NF-κB and PGC-1α in skeletal muscle.
Key words: p53, RelA/p65, PGC-1α, acute exercise, mitophagy
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