Association of VEGF protein expression according to muscle fiber types with diet and exercise intervention in diet-induced obese rats

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doi:2013.22.1.86

Exerc Sci > Volume 22(1); 2013 > Article

Exercise Science 2013;22(1): 86-94. doi: https://doi.org/10.15857/ksep.2013.22.1.86

비만 흰쥐의 6주간 식이와 운동 처치후 골격근 유형별 VEGF 단백질 발현의 변화.

홍창배, 천우광, 김기진

계명대학교

Association of VEGF protein expression according to muscle fiber types with diet and exercise intervention in diet-induced obese rats

Published online: December 14, 2015.

ABSTRACT

This study measured vascular endothelial growth factor (VEGF) protein expression of different skeletal muscle fiber types after a 6-week intervention of energy restriction and exercise in diet-induced obese rats. The changes in protein expression were analyzed across the different 6-weeks intervention programs of diet, exercise, and diet plus exercise. After intake of high fat diet for 6-weeks, obesity-induced groups showed a significantly higher body weight as compared to control group. The diet plus exercise (B) group showed a significantly lower visceral fat volume after 6-weeks, and obese group showed a higher visceral fat volume than the other groups. Diet alone group, and diet plus exercise (B) group showed a significantly higher VEGF protein expression in red gastrocnemius muscle after 6-weeks of treatment as compared to the pre-level of control group. The diet alone group, exercise group, and diet plus exercise (B) groups showed a significantly higher VEGF protein expression in white gastrocnemius muscle after 6-weeks of treatment as compared to the pre-level of obese group, but these groups showed no significant differences as compared to the pre-level of control group. The exercise group showed a significantly higher VEGF protein expression in soleus muscle after 6-weeks of treatment as compared to the pre-level of the control group, and the exercise group and diet group showed a significantly higher VEGF protein expression in soleus muscle after 6-weeks of treatment as compared to the post-level of the control group. In conclusion, VEGF protein expression of type IIb fibers in gastrocnemius white muscle showed a significant activation after exercise.

Key words: Vascular endothelial growth factor (VEGF), Obesity, Diet, Exercise