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Treadmill exercise increases muscle satellite cell activation independent of oxygen concentration in rat
Changhyun Lim1, Heejeong Son2
1Korea National Sport University, seoul, Korea
2Center for sport science in gyeonggi, Suwon, Korea
Correspondence  Heejeong Son , Tel: +82-010-5263-5717, Fax: +82-2-410-6945, Email: son1106@ggsc.or.kr
Received: October 22, 2018;  Accepted: November 29, 2018.  Published online: November 29, 2018.
ABSTRACT
PURPOSE:
This study was performed to investigate the effect of hypoxia in conjugation with endurance exercise training on skeletal muscle satellite cell activity in rats.
METHODS:
Sprague-Dawley rats (20wk, N=21) were randomly divided into Control (Con, n=7), normoxia exercise (NE, n=7), and hypoxia exercise (HE, n=7) groups. Exercise training was performed on a rodent treadmill at a frequency of 5 days/week for 4 weeks, with gradual increases in exercise intensity. The rats were sacrificed 48 hours following the last exercise session. We conducted immunohistochemistry and western-blot for evaluating satellite cell cycle in phenotype and protein levels.
RESULTS:
Any groups did not increase body weight, muscle weight and cross-sectional area were not increased in any groups after 4 weeks (p>.05). Satellite cell proliferation improved in NE (p=.001) and HE (p<.001) groups. NE (p=.028) and HE (p<.001) groups significantly increased the number of centrally-located myonucei compared to Con.
CONCLUSIONS:
Treadmill exercise can induce satellite cell proliferation and differentiation regardless of oxygen partial pressure in the air, and increasing muscle metabolism efficiency is expected through muscle remodeling by satellite cell activation.
Key words: Hypoxia; Satellite cell; Treadmill exercise; Myonuclear; Central myonuclear; 저산소
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Treadmill Exercise Increases Muscle Satellite Cell Activation Independent of Oxygen Concentration in Rat  2019 February;28(1)
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