Effects of Exercise on Genes Expression of the Reverse Cholesterol Transport Pathway in Middle-Aged Women.

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doi:2012.21.1.59

Exerc Sci > Volume 21(1); 2012 > Article

Exercise Science 2012;21(1): 59-68. doi: https://doi.org/10.15857/ksep.2012.21.1.59

운동이 중년여성 말초단핵구세포의 reverse cholesterol transport pathway 유전자 발현에 미치는 영향

조진경¹, 김영민¹, 진영윤², 하창덕¹, 최규환¹, 홍혜련¹, 이신호¹, 강현식¹

¹성균관대학교
²국민체육진흥공단체육과학연구원

Effects of Exercise on Genes Expression of the Reverse Cholesterol Transport Pathway in Middle-Aged Women.

ABSTRACT

The purpose of the present study was to investigate the effects of both acute exercise and exercise training on blood lipids and mRNAs expression of RCT pathway in middle-aged women (n=8). In a single-group cross-over design, subjects performed a 3-day consecutive exercise at an intensity of 65% VO2max targeting at energy expenditure of 1,200 kcal (400 kcal/day) and a 3-day control period. And they were further asked to participate in a 4-week exercise training at the same intensity of 65% VO2max with a frequency of 3 days per week. The measured outcomes of the study included body composition (i.e., weight, body mass index, body fat, waist circumference), blood lipoprotein lipids (i.e., triglycerides, total cholesterol, high-density lipoprotein cholesterol, apolipoprotein A-1) and RCT pathway mRNAs (i.e., ABCA1 mRNA, ABCG1 mRNA, SR-B1 mRNA) in peripheral blood mononuclear cells (PBMC). One-way RM ANOVA followed by LSD post-hoc and paired t-test were utilized to test any significant changes in the outcomes of the acute exercise and exercise training, respectively. The findings of the study showed that 1) acute exercise induced a significant decrease in serum triglycerides, with no other significant changes in any of the measured variables and 2) unlike acute exercise, exercise training resulted in significant increases in high-density lipoprotein cholesterol and apolipoprotein A-1 as well as a significant increase in PBMC ABCG1 mRNA. In summary, the current findings of the study suggest that aerobic exercise training can contribute to improved RCT pathway functioning in middle-aged women as shown in increases in HDLC, apoA-1, and ABCG1 mRNA.

Key words: Exercise training, RCT pathway, High-density lipoprotein cholesterol, Apolipoprotein A-1