| 장기간 중강도 운동훈련과 일회 탈진운동이 쥐 비장세포의 싸이토카인 생성량 및 증식반응에 미치는 영향 |
| 이왕록, 정준현, 박희근, 전종귀, 윤아람, 권순미, 김명화 |
| 충남대학교 |
| Effects of acute exhaustive exercise and long-term moderate exercise training on splenocyte immunocompetence in mice |
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| ABSTRACT |
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The present research was to investigate the effect of exhaustive exercise and long-term moderate exercise training on splenocyte immunoresponse in mice. Male Balb/c mice (4 weeks, n = 30) were used and randomly divided into 3 groups; Control group (CON, n=10), Exhaustive exercise group (EXH, n=10, 14-28 m/min, 5%, ≒90 min at 16 weeks) and Moderate exercise training group (TRA, n=10, 10-14 m/min, 30-50 min/day, 5 day/week for 16 weeks). After exercise training, all the splenocyte was collected and multiful doses of Con A(Concanavalin A) were used to stimulate the cells. Then, IL-1β, IL-4, IL-12, IFN-γ and cell proliferation were measured by commercial ELISA kits. One-way ANOVA were used and p value under 0.05 was considered as statistical significance. IL-12 production of exhaustive exercise was higher than other groups. However, IL-1β, IL-4, IFN-γ and cell proliferation and were not significantly affected by both exhaustive exercise and a long-term moderate exercise training. In conclusion, exhaustive exercise could enhance to produce IL-12 cytokine(Th1 cytokine) in splenocyte, which help cell-mediated immunity. Further exercise-induced immunocompetence would be different in each immune cells. |
| Key words:
moderate exercise training, exhaustive exercise, spleen, cytokine, proliferation |
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