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Exerc Sci > Volume 19(2); 2010 > Article
Exercise Science 2010;19(2): 115-130. doi: https://doi.org/10.15857/ksep.2010.19.2.115
식이유도 비만 생쥐의 식이제한과 운동처치 후 대식세포와 단핵구의 IL-6 및 TNF-α 생성의 변화
김기진
계명대학교
Changes of IL-6 and TNF-α production by macrophages and monocytes after restricted diet and exercise training intervention in diet-induced obese mice.
ABSTRACT
This study was performed the analysis of blood cell numbers related immune function and lipopolysaccharide (LPS) stimulated production of tumor necrosis factor (TNF)-α and interleukin (IL)-6 by retroperitoneal macrophage in diet-induced obesity and obesity intervention of male C57Bl/6 mice. Diet-induced obesity was fed a high-fat or a standard chow diet for 6 weeks, and obesity intervention was drived by treadmill running exercise program or food intake restriction. Test items were measured by blood cell numbers related immune function and LPS stimulated production of TNF-α and IL-6 by retroperitoneal macrophage. Subjects of diet-induced obesity showed a significant increase of body weight as compared to normal diet group. High fat diet (HFD)-diet restriction (DR), HFD-exercise (EX) and HFD-DR-EX groups showed a significant decrease of body weight after 8 week intervention as compared to HFD-HFD group. And HFD-DR showed the highest decrease of body weight among intervntion groups. Diet-induced obese groups showed a decreasing tendency of blood cell numbers related immune function, and the intervention groups showed an increase of blood cell numbers related immune function after 8 week intervention. LPS stimulated production of TNF-α by retroperitoneal macrophage in diet-induced obesity showed a significant decrease than a ND group, and LPS stimulated production of TNF-α and IL-6 by retroperitoneal macrophage in intervention groups showed a significant decrease after 8 week of food intake restriction or exercise training. In conclusion, diet-induced obesity showed a attenuation of immune function, and improved the blood cell numbers related immune function and LPS stimulated production of TNF-α and IL-6 by retroperitoneal macrophage after exercise intervention and food intake restriction.
Key words: obesity, diet, exercise, cytokine, immune function, macrophage, TNF-α
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