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Exerc Sci > Volume 21(1); 2012 > Article
Exercise Science 2012;21(1): 51-58. doi: https://doi.org/10.15857/ksep.2012.21.1.51
트레드밀 운동이 6-OHDA로 유발된 파킨슨병 흰쥐 흑색질 내 염증지표에 미치는 영향
조한샘1, 신말순1, 김창주1, 백성수2
1경희대학교
2상명대학교
Effect of treadmill exercise on inflammatory markers in the substantia nigra in 6-OHDA-induced Parkinson's rats.
ABSTRACT
In the present study, we investigated the effects of treadmill exercise on inflammatory reaction in the substantia nigra of the Parkinson's rats. Parkinson's disease was made by injection of 6-hydroxydopamine (6-OHDA) into the striatum using 6-week-old male rats. The rats were divided into 4 groups: sham-operation group (n=10), sham-operation and exercise group (n=10), 6-OHDA-injection group (n=10), and 6-OHDA-injection and exercise group (n=10). The animals in the exercise groups were put on the treadmill to run for 30 minutes once a day for 14 consecutive days, starting 4 weeks after 6-OHDA injection. For the detection of inflammatory reaction in the substantia nigra, immunohistochemistry for cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) was performed. The number of COX-2-positive cells in substantia nigra was 54.19±3.68 in the sham-operation group, 42.94±3.01 in the sham-operation and exercise group, 98.22±4.73 in the 6-OHDA-injection group, and 61.78±3.86 in the 6-OHDA-injection and exercise group. The number of iNOS-positive cells in substantia nigra was 57.93±3.38 in the sham-operation group, 51.64±5.17 in the sham-operation and exercise group, 126.56±7.04 in the 6-OHDA-injection group, and 92.69±8.28 in the 6-OHDA-injection and exercise group. In the present results, 6-OHDA injection increased inflammatory reaction in the substantia nigra, and treadmill exercise alleviated the expression of COX-2 and iNOS in the substantia nigra. These results suggest that treadmill exercise may ameliorate inflammatory reaction in the Parkinson's disease patients.
Key words: Parkinson’s disease, 6-hydroxydopamine, Treadmill exercise, Cyclooxygenase-2, Inducible nitric oxide synthase
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