| 유산소운동이 2형 당뇨쥐 골격근 미토콘드리아의 PGC-1α, AMPK 및 SOD 발현에 미치는 영향 |
| 김상배1), 김종오2), 윤진환2), 김대성3), 이상학4)* |
1강원대학교 스포츠과학부
2한남대학교 생활체육학과
3서남대학교 생활체육학과
4청주대학교 생명과학과 |
| Effects of Aerobic Exercise on PGC-1α, AMPK and SOD Expression of Skeletal Muscle in 2Type Diabetic Rats |
| Sang-Bae Kim1), Jong-Oh Kim2), Jin-Hwan Yoon2), Dae-Sung Kim3), Sang-Hak Lee4)* |
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| Correspondence |
Sang-Hak Lee , Tel: +82-43-229-8525, Fax: +82-43-229-8525, Email: 2594119@gmail.com
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Received: June 30, 2015; Accepted: August 4, 2015. Published online: August 30, 2015. |
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| ABSTRACT |
PURPOSE:
The purpose of this study was to investigate the effect of aerobic exercise on PGC-1α, AMPK and SOD expression of skeletal muscle in type diabetic rats.
METHODS:
Thirty male C57BL/KsJ-db/db of 7 weeks old, were used. Experimental groups were randomly divided into 3 groups: DM (diabetic control group, n=10), DM+Ex (diabetic exercise group, n=10), CON (control group, n=10). In the exercised groups, the mice exercise treadmill for 30 min/day (14-16 m/min), 5 days/week for 8 weeks.
RESULTS:
Data analysis was done by computer using SPSS (Ver.18.0) and one-way ANOVA; the results of this study are as follows: the DM+Ex group showed a significant increase in PGC-1α, AMPK and SOD activity of mitochondrial proteins compared to the control DM group (p<.05).
CONCLUSIONS:
In conclusion, regular mid-intensity exercise increases the activity of mitochondrial proteins (PGC-1α, AMPK and SOD) of skeletal muscle of 2 type diabetic rats. And than the exercise is considered a helpful way to improve mitochondrial function and insulin sensitivity. |
| Key words:
mitochondria, treadmill exercise, insulin resistance |
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