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Exerc Sci > Volume 24(3); 2015 > Article
Exercise Science 2015;24(3): 297-303. doi: https://doi.org/10.15857/ksep.2015.24.3.297
유산소운동이 2형 당뇨쥐 골격근 미토콘드리아의 PGC-1α, AMPK 및 SOD 발현에 미치는 영향
김상배1), 김종오2), 윤진환2), 김대성3), 이상학4)*
1강원대학교 스포츠과학부
2한남대학교 생활체육학과
3서남대학교 생활체육학과
4청주대학교 생명과학과
Effects of Aerobic Exercise on PGC-1α, AMPK and SOD Expression of Skeletal Muscle in 2Type Diabetic Rats
Sang-Bae Kim1), Jong-Oh Kim2), Jin-Hwan Yoon2), Dae-Sung Kim3), Sang-Hak Lee4)*
Correspondence  Sang-Hak Lee , Tel: +82-43-229-8525, Fax: +82-43-229-8525, Email: 2594119@gmail.com
Received: June 30, 2015;  Accepted: August 4, 2015.  Published online: August 30, 2015.
The purpose of this study was to investigate the effect of aerobic exercise on PGC-1α, AMPK and SOD expression of skeletal muscle in type diabetic rats.
Thirty male C57BL/KsJ-db/db of 7 weeks old, were used. Experimental groups were randomly divided into 3 groups: DM (diabetic control group, n=10), DM+Ex (diabetic exercise group, n=10), CON (control group, n=10). In the exercised groups, the mice exercise treadmill for 30 min/day (14-16 m/min), 5 days/week for 8 weeks.
Data analysis was done by computer using SPSS (Ver.18.0) and one-way ANOVA; the results of this study are as follows: the DM+Ex group showed a significant increase in PGC-1α, AMPK and SOD activity of mitochondrial proteins compared to the control DM group (p<.05).
In conclusion, regular mid-intensity exercise increases the activity of mitochondrial proteins (PGC-1α, AMPK and SOD) of skeletal muscle of 2 type diabetic rats. And than the exercise is considered a helpful way to improve mitochondrial function and insulin sensitivity.
Key words: mitochondria, treadmill exercise, insulin resistance
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