| 복부비만으로 인한 인슐린 저항성 유발에 관한 기전 연구 |
| 이신호, 조진경, 김동현, 강현식 |
| 성균관대학교 |
| A study on the mechanism of insulin resistance induction by abdominal obesity |
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| ABSTRACT |
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The purpose of this study was a study on the mechanism of insulin resistance induction by to compare the energy metabolic gene expression in abdominal subcutaneous adipose tissues between non-obesity(NO) and obesity+insulin resistance(OI) groups. No significant differences in physical activity, dietary intake and cardiorespiratory fitness but significant(p<.002, p<.004, p<.010) differences in body mass index, waist circumference, and a 2-hr oral glucose tolerance test. and significant(p<.043, p<.043, p<.025, p<.019, p<.005) differences in Hemoglobin A1c(HbA1c), mean plasma glucose(MPG), fasting blood insulin(FBI), area under curve for glucose(AUC glucose), homeostasis model of assessment for insulin resistance (HOMA-IR) but No significant differences in fasting blood glucose(FBG) and area under curve for insulin(AUC insulin). As compared with the NO group, the OI group had significantly lower AMPK(p=.044) and GFAT(p=.016) mRNA expressions. No significant differences in mRNA expressions were found between the NO and OI groups in the mTOR pathway and the insulin signalling pathway. The current findings of the study suggest that abdominal obesity along with insulin resistance can decrease AMPK mRNA and GFAT mRNA expressions in abdominal subcutaneous adipose tissue in middle-aged women. |
| Key words:
energy metabolic regulatory network, AMPK pathway, mTOR pathway, hexosamine pathway, insulin pathway |
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