The Effect of Isocaloric Medium-Chain Fat Diet and Aerobic Exercise on Mitochondrial Biogenesis and Endurance Exercise Capacity in Aged Rat

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doi:2014.23.2.119

Exerc Sci > Volume 23(2); 2014 > Article

Exercise Science 2014;23(2): 119-127. doi: https://doi.org/10.15857/ksep.2014.23.2.119

등열량 중쇄지방식이와 유산소성 운동이 노화쥐의 골격근내 미토콘드리아 생합성과 지구성 운동능력에 미치는 영향

정수련¹, 김기진²

¹경주대학교
²계명대학교

The Effect of Isocaloric Medium-Chain Fat Diet and Aerobic Exercise on Mitochondrial Biogenesis and Endurance Exercise Capacity in Aged Rat

ABSTRACT

The purpose of this study was to investigate the effects of isocaloric medium-chain fat diet and aerobic exercise on mitochondrial biogenesis and endurance exercise capacity in aged rat. 50-week-old male Wistar rat were randomly assigned for 4 group (Chow; isocaloric medium-chain fat diet, MF; endurance exercise, Ex; diet/exercise combined group, Mex). After 4 weeks, body weight did not changed between groups, but visceral fat were significantly increased in MF and Mex. Fasting plasma glucose and insulin level also significantly increased in MF and Mex. Endurance exercise capacity was significantly decreased in Mex compared with Ex. In addition, endurance exercise capacity of Mex group was significantly lower than Ex group. However, the skeletal muscle mitochondrial biosynthesis marker was significantly increased in MF, Ex, and Mex. In summary, although the isocaloric medium-chain fat diet increased mitochondrial biogenesis despite generates insulin resistance, endurance exercise capacity does not increase, respectively. Thus, the use of medium-chain fat diet needs more research for old people.

Key words: isocaloric medium-chain fat, aerobic exercise, mitochondrial biogenesis, endurance exercise capacity