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Exerc Sci > Volume 21(2); 2012 > Article
Exercise Science 2012;21(2): 191-200. doi: https://doi.org/10.15857/ksep.2012.21.2.191
일회성 유산소 운동에 따른 흰쥐 비복근 내 미토콘드리아 기능 및 구조 조절 단백질의 발현
김정하, 김재철, 박대령, 강윤석
전북대학교
The effect of acute exercise on the expression of mitochondria functiom and content protein in rat skeletal muscle
ABSTRACT
The aim of this study was to investigate the expression of Drp 1, Mfn 2, PGC-1α, p53 and αB-crystallin protein in the skeletal muscle of Sprague-Dawley rats by endurance exercise(26 m/min, 10°,45 min, 90 min, recovery 12 h). The expression of Drp 1, Mfn 2, PGC-1α, p53 and αB-crystallin protein in skeletal muscle analyzed by western blotting. The expression of Drp 1, Mfn 2 and PGC-1α protein significantly were increased in red gastrocnemius during exercise(45 min) and recovery 12 h. The expression of B-crystallin protein significantly were increased in red gastrocnemius during exercise(45 min). The expression of p53 protein in both red and white gastrocnemius was increased in all periods. These findings suggest that Drp 1, Mfn 2, PGC-1α, p53 and αB-crystallin protein plays a role of mitochondrial homeostasis in skeletal musce by endurance exercise.
Key words: acute endurance exercise, skeletal muscle, Drp 1, Mfn 2, PGC-1α, p53, αB-crystallin
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