The expression of p53, pFoxO-1 and MuRF1 protein in skeletal muscle during intensity endurance training.

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doi:2011.20.4.379

Exerc Sci > Volume 20(4); 2011 > Article

Exercise Science 2011;20(4): 379-388. doi: https://doi.org/10.15857/ksep.2011.20.4.379

고강도 지구성 운동이 골격근내 p53, p-FoxO1 및 MuRF1 단백질의 발현에 미치는 영향

강윤석, 김정하, 유성경, 박대령, 김재철

전북대학교

The expression of p53, pFoxO-1 and MuRF1 protein in skeletal muscle during intensity endurance training.

ABSTRACT

The aim of this study was to investigate the expression of p53, p-FOXO-1, and MuRF-1 protein in the skeletal muscle of Sprague-Dawley rats during intensity endurance exercise (26 m/min, 10°, 15 min, 30 min, 45 min, 60 min, 90 min). The expression of p53, p-FoxO1, and MuRF1 protein in skeletal muscle by western blotting. The expression of p53, p-FoxO1, and MuRF1 protein significantly were increased at 15min to 30 min during intensity endurance exercise and then gradually returned to bofore exercise level. These finding suggest that p53, p-FoxO1, and MuRF1 protein plays a role in the maintennance of homeostasis in skeletal muscle during intensity endurance exercise.

Key words: Intensity endurance exercise, Sprague-Dawley rat, Skeletal muscle, p53, p-FoxO1, MuRF1