Expression of αB-crystallin, HSP 27, HSP 70 and muscle damage factors in rat skeletal muscle following acute endurance exercise and recovery

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doi:2009.18.3.285

Exerc Sci > Volume 18(3); 2009 > Article

Exercise Science 2009;18(3): 285-294. doi: https://doi.org/10.15857/ksep.2009.18.3.285

일회성 운동 및 회복기 흰쥐 골격근 내 Small HSP 및 HSP 70과 골격근 손상인자 발현 양상에 대한 연구

박대령, 윤정수, 임채일, 하태균

전북대학교

Expression of αB-crystallin, HSP 27, HSP 70 and muscle damage factors in rat skeletal muscle following acute endurance exercise and recovery

ABSTRACT

This study was to investigate to the expression of αB-crystallin, HSP 27, HSP 70 and muscle damage factor by acute endurance exercise and recovery. The Male SD rat ran the treadmill running for 90min 26M/min, 10° intensity and Soleus and extensor digitorum longus muscle was extracted at 15, 30, 45, 60, 90 min in exercise period and 6H, 12H, 24H, 36H, 48H in recovery period. Expression of αB-crystallin, HSP 27, HSP 70 and muscle damage factor were analyzed by western blotting. The expression of αB-crystallin, HSP 27 was significantly increased in early phase of exercise and HSP 70 was significantly increased in recovery period. The expression of cytosolic cytochrome c were significantly increased in recovery period. These results suggests that the small HSPs may function as stabilizer of disrupted myofibrillar structure at the early stage of execise. and Delayed HSP 70 expression at the recovery period showed that the HSP 70 was involved in recovery and remodeling and adaptation processed in skeletal muscle.

Key words: oxidative stress, small HSP, delayed HSP 70 expression