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Exerc Sci > Volume 14(2); 2005 > Article
Exercise Science 2005;14(2): 109-120.
지구성 운동이 비만 쥐 골격근의 PPARδ와 PGC-1α의 발현 및 효소 활성도에 미치는 영향
신영오1, 강호율2, 오재근1, 김영주1, 박수연1, 김호성1, 권기욱1, 이종삼3
1한국체육대학교
2경북대학교
3을지의과대학교
Effect of exercise training on protein expression of PPARδ and PGC-1α in obese Zucker rat skeletal muscles.
ABSTRACT
Shin, Y.O., Lee, J.S., Park, S.Y., Kang, H.Y., Kim, Y.J., Kim, H.S., Kwon, K.W., Oh, J.K. Effect of exercise training on protein expression of PPARδ and PGC-1α in obese Zucker rat skeletal muscles. Exercise Science, 14(2): 109-120, 2005. Recent emerging evidences suggested that peroxisome proliferator-activated receptor δ (PPARδ), and peroxisome proliferator-activated receptorγ coactivator 1α (PGC-1α) play a pivotal role in fatty acid oxidation. Present study investigated regulatory effects of exercise training on PPARδ and PGC-1α in insulin resistance obese Zucker rats. Investigation was further extended in two different (soleus, SOL(type I) vs. extensor digitorum logus, EDL(type II)) muscle fiber types, mitochondrial oxidative enzyme activity were analysed. After 8 weeks of treadmill running procedure, oral glucose tolerance test (OGTT; 2gkg-1 body mass; BM) were underwent in all groups(lean Zucker control rats; LN, obese Zucker control rats; OB, exercise-trained obese Zucker rats; EXE) and blood glucose, insulin, and free fatty acids levels were measured. Exercise training significantly improved insulin sensitivity and blood lipid profiles. Activity of citrate synthase(CS) and β-Hydroxyacyl-CoA Dehydrogenase (β-HAD) in SOL was increased significantly, but not in EDL. PGC-1α protein contents was not different between OB and LN in both of muscle fiber types. However, PPARδ protein contents was significantly deceased in SOL of OB than LN. Exercise training significantly elevated protein expression of PGC-1α and PPARδ from OB in both muscle fiber types. These findings indicate that adaptation of skeletal muscles to exercise training increased in protein expression of PPARδ and PGC-1α associated with fatty acid oxidation.
Key words: obesity, exercise, insulin resistance, oral glucose tolerance test, muscle fiber types, PPARδ, PGC-1α.
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