Effects of endurance aerobic exercise on apoptosis in the hippocampus of the rat pups with maternal infection-induced cerebral palsy

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doi:2009.18.4.489

Exerc Sci > Volume 18(4); 2009 > Article

Exercise Science 2009;18(4): 489-496. doi: https://doi.org/10.15857/ksep.2009.18.4.489

지구성 유산소 운동이 모체감염으로 유발된 뇌성마비 새끼 쥐 해마의 세포사멸에 미치는 영향

서진희¹, 김기정², 김대영¹, 성윤희¹, 신말순¹, 김창주¹, 김영표³

¹경희대학교
²서울대학교
³제주대학교

Effects of endurance aerobic exercise on apoptosis in the hippocampus of the rat pups with maternal infection-induced cerebral palsy

ABSTRACT

In the present study, we investigated the effects of endurance aerobic exercise, swimming or treadmill running, on apoptosis in the hippocampus of the rat pups with maternal infection-induced cerebral palsy (CP). CP in the neonatal rats was induced by intraperitoneal injection of 0.15 mg/kg lipopolysaccharide to the pregnant rats at gestation day 15, 17, and 20. The neonatal rats were divided into four groups: the control group, the CP-induction group, the CP-induction and swimming group, and the CP-induction and treadmill running group (n = 5 in each group). After 12 weeks of birth, the rat pups in the swimming group and in the running group were made to perform each exercise for 30 min once a day for 5 times per week during 2 weeks. The rat pups with CP showed decreased expression of anti-apoptotic protein Bcl-2, while increased expressions of pro-apoptotic proteins Bax, caspase-3, Fas, and cytochrom c(p<.05). Swimming or treadmill running, enhanced Bcl-2 protein expression, in contrast, suppressed Bax, caspase-3, Fas, and cytochrom c expressions in the hippocampus of the rat pups with cerebral palsy(p<.05). The present study revealed that endurance aerobic exercise is helpful intervention for the treatment of maternal infection-induced brain damage.

Key words: endurance aerobic exercise, cerebral palsy, apoptosis, Bcl-2, Bax, caspase-3, Fas