| 지구성 유산소 운동이 모체감염으로 유발된 뇌성마비 새끼 쥐 해마의 세포사멸에 미치는 영향 |
| 서진희1, 김기정2, 김대영1, 성윤희1, 신말순1, 김창주1, 김영표3 |
1경희대학교
2서울대학교
3제주대학교 |
| Effects of endurance aerobic exercise on apoptosis in the hippocampus of the rat pups with maternal infection-induced cerebral palsy |
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| ABSTRACT |
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In the present study, we investigated the effects of endurance aerobic exercise, swimming or treadmill running, on apoptosis in the hippocampus of the rat pups with maternal infection-induced cerebral palsy (CP). CP in the neonatal rats was induced by intraperitoneal injection of 0.15 mg/kg lipopolysaccharide to the pregnant rats at gestation day 15, 17, and 20. The neonatal rats were divided into four groups: the control group, the CP-induction group, the CP-induction and swimming group, and the CP-induction and treadmill running group (n = 5 in each group). After 12 weeks of birth, the rat pups in the swimming group and in the running group were made to perform each exercise for 30 min once a day for 5 times per week during 2 weeks. The rat pups with CP showed decreased expression of anti-apoptotic protein Bcl-2, while increased expressions of pro-apoptotic proteins Bax, caspase-3, Fas, and cytochrom c(p<.05). Swimming or treadmill running, enhanced Bcl-2 protein expression, in contrast, suppressed Bax, caspase-3, Fas, and cytochrom c expressions in the hippocampus of the rat pups with cerebral palsy(p<.05). The present study revealed that endurance aerobic exercise is helpful intervention for the treatment of maternal infection-induced brain damage. |
| Key words:
endurance aerobic exercise, cerebral palsy, apoptosis, Bcl-2, Bax, caspase-3, Fas |
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