Effect of endurance treadmill exercise on motor, emotional, and cognitive functions in developing rats with maternal infection -induced cerebral palsy

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doi:2009.18.3.401

Exerc Sci > Volume 18(3); 2009 > Article

Exercise Science 2009;18(3): 401-408. doi: https://doi.org/10.15857/ksep.2009.18.3.401

지구성 트레드밀 운동이 모체감염으로 유발된 뇌성마비 쥐의 운동기능, 정서기능 및 인지기능에 미치는 영향

김기정¹, 서진희², 김보균², 김대영³, 성윤희², 김창주², 진현지⁴, 김영표⁴

¹서울대학교
²경희대학교
³경운대학교
⁴제주대학교

Effect of endurance treadmill exercise on motor, emotional, and cognitive functions in developing rats with maternal infection -induced cerebral palsy

ABSTRACT

Effect of endurance treadmill exercise on motor, emotional, and cognitive functions in developing rats with maternal infection -induced cerebral palsy. Exercise Science. 18(3): 401-408, 2009. In the present study, we investigated the effect of endurance treadmill exercise on motor, emotional, and cognitive function in developing rats with maternal infection-induced cerebral palsy. In this study, the cerebral palsy was induced by intraperitoneal injection of lipopolysaccharide 0.15 mg/kg to the pregnant rats at gestation day 15, 17, and 20. The treadmill exercise load consisted of running at a speed of 8 m/min in the mild exercise group and 14 m/min in the moderate exercise group for 30 min once a day during 4 weeks. The present results showed that induction of cerebral palsy did not affect emotional function, however, it decreased motor and cognitive function. Endurance treadmill exercise ameliorated the disturbance of cognitive function induced cerebral palsy. These results suggest that endurance treadmill exercise may be used for the treatment of cerebral palsy to improve cognitive function.

Key words: exercise, cerebral palsy, open field test, elevated plus maze test, step-down avoidance task