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Exerc Sci > Volume 19(1); 2010 > Article
Exercise Science 2010;19(1): 15-26. doi: https://doi.org/10.15857/ksep.2010.19.1.15
장기간 운동이 마우스 조직별 heme oxygenase-1 발현에 미치는 영향
김시영
서울대학교
Effects of long-term treadmill exercise on heme oxygenase-1 expression in mouse tissues
ABSTRACT
Heme oxygenase (HO)-1, involved in the heme degradation process, is upregulated by a wide array of stimuli and has antioxidant, anti-inflammatory and other cytoprotective functions. The aim of this study was to investigate the difference and effect of long-term exercise on HO-1 expression among mouse tissues. The study carried out on twenty-four ICR mice. All mice participated in this study which consisted of three groups [control group (CONT, n=8), low-intensity exercise group (LIE, n=8), high-intensity exercise group (HIE, n=8)]. Mice were euthanized after 16 weeks of training periods and tissues (skeletal muscle, colon, heart, lung, liver, and brain) were removed. As a result of analyzed difference of HO-1 expression among tissues, liver topped the list, followed by colon, lung, heart, skeletal muscle, and brain (p<.001). In case of skeletal muscle, colon, and liver, after training for 16 weeks, HO-1 expression in HIE and/or LIE dramatically increased in comparison with CONT (p<.01, p<.001). On the other hand, no significant differences in the heart, lung, and brain were found between all groups. Taken together, we conclude that level of HO-1 expression is different between mouse tissues and long-term regular exercise can enhance the levels of HO-1 expression in skeletal muscle, colon, and liver.
Key words: Heme oxygenase-1, Long-term Exercise, Mouse Tissues
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